#1 Uffizi Gallery
The Renaissance shines brightest in Florence. Within the city's artistic and architectural legacy, the Uffizi Gallery stands out. Designed by Vasari in 1580 for the Medici family, this riverside landmark is now a premier museum. Across two floors and 45 rooms, works by Raphael, Botticelli, Da Vinci, Caravaggio, and Michelangelo reach global acclaim.